Foreign function interfaces (FFIs) allow programs written in one language (called the host language) to call functions written in another language (called the guest language), and are widespread throughout modern programming languages, with C FFIs being the most prevalent. Unfortunately, reasoning about C FFIs can be very challenging, particularly when using traditional methods which necessitate a full model of the guest language in order to guarantee anything about the whole language. To address this, we propose a framework for defining whole language semantics of FFIs without needing to model the guest language, which makes reasoning about C FFIs feasible. We show that with such a semantics, one can guarantee some form of soundness of the overall language, as well as attribute errors in well-typed host language programs to the guest language. We also present an implementation of this scheme, Poseidon Lua, which shows a speedup over a traditional Lua C FFI.